1997年至2001年就读于日本歧阜大学医学部获医学/哲学博士学位。2001至2006年曾先后在美国国家卫生研究院(NIH),国家癌症研究所(NCI);美国宾夕法尼亚大学(PENN)医学院工作;从事分子肿瘤学与遗传学研究。於2006年从美国回国,复旦大学生命科学学院遗传工程国家重点实验室任课题组长及教授。
基本信息
出生年月:1970年1月
职称:教授
简历
1997年至2001年就读于日本歧阜大学医学部获医学/哲学博士学位。2001至2006年曾先后在美国国家卫生研究院(NIH),国家癌症研究所(NCI);美国宾夕法尼亚大学(PENN)医学院工作;从事分子肿瘤学与遗传学研究。於2006年从美国回国,复旦大学生命科学学院遗传工程国家重点实验室任课题组长及教授。
主要研究方向
⒈分子肿瘤学与遗传学;着重于抑癌基因的生物学调控
⒉肿瘤治疗特异性靶标的发现与新药开发
⒊Tetrahymena模式生物在功能基因组学研究中的应用
获奖情况
2003年获美国癌症研究学会(AACR)颁发的“Scholar-in-training”奖;於2002年获美国国家卫生研究院(NIH)颁发的VisitingFellowship;曾作为美国的癌症研究领域的权威杂志CancerResearch的审稿人。
著作论文
研究工作先后在PNAS,CancerCell,CancerResearch,Mol.Cell.Biol.及Oncogene等国际核心刊物上发表(20余篇)。曾有5次在国际学术会议上发表。
⒈WangSandEl-DeiryW.p73orp53directlyregulatehumanp53transcriptiontomaintaincellcyclecheckpoints.CancerResearch66:6982-6989,2006
⒉WangSandEl-DeiryW.p53,cellcyclearrestandapoptosis.25yearsofp53researcheditedbyPierreHainautandKlasWiman:141-163,2005
⒊FeiP,WangW,KimS,WangS,BurnsTF,SaxJK,BuzzaiM,DickerDT,MckennaWG,BernhardEJandEl-Deiry,W.Bnip3Lisinducedbyp53underhypoxia,anditsknockdownpromotestumorgrowth.CancerCell6:597-609,2004
⒋WangSandEl-DeiryW.InduciblesilencingofKILLER/DR5promotesbioluminescenttumorxenograftsgrowthandconfersresistancetochemotherapeuticagent5-Fluorouracil.CancerResearch64:6666-6672,2004
⒌WangSandEl-DeiryW.Apoptosissignalinginnormalandcancercells.Cellcycleandgrowthcontrol-BiomolecularregulationandcancereditedbyGarySteinandArthurB.Pardee,497-521,2004
⒍WangSandEl-DeiryW.Thep53pathway:Targetsforthedevelopmentofnovelcancertherapeutics.CancerTreatmentandResearcheditedbyRaheshKumar175-187,2004
⒎WangSandEl-DeiryW.Cytochromec:Acrosslinkbetweenthemitochondriaandtheendoplasmicreticulumincalcium-dependentapoptosis.CancerBiologyandTherapy3⑴:15095-15100,2004
⒏WangSandEl-DeiryW.Requirementofp53targetsinchemosensitizationofcoloniccarcinomatodeathligandtherapy.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica100(25):15095-15100,2003
⒐WangSandEl-DeiryW.TRAILandapoptosisinductionbyTNF-familydeathreceptors.Oncogene22:8628-8633,2003
⒑KumaraswamyE,CarlsonBA,MorganF,MiyoshiK,RobinsonGW,SuD,WangS,SouthonE,TessarolloL,LeeBJ,GladyshevVN,HennighausenLandHatfieldDL.SelectiveremovaloftheselenocysteinetRNA[Ser]Secgene(Trsp)inmousemammaryepithelium.MolecularCellularBiology,23⑸:1477-88,2003
⒒KodaM,MurateT,WangS,OhguchiK,IkedaM,Tamiya-KoizumiK,IgarashiY,NozawaYandBannoY.Sphingosinekinase1isinvolvedindibutyrylcyclicAMP-inducedgranulocyticdifferentiationthroughup-regulationofextracellularsignal-regulatedkinase,butnotp38MAPkinase,inHL60cells.Biochim.Biophys.Acta,1733(2-3):101-10,2005.
⒓WangS,BannoYandNozawaY.Twoformsofmembrane-boundsphingosinekinaseinTetrahymenaandactivitychangesduringgrowthandthecellcycle.JournalofEukaryoticMicrobiology,49⑵:305-311,2002
⒔BannoY,WangS,ItoY,IzumiT,NakashimaS,ShimizuTandNozawaY.Bothextracelluarregulatedproteinkinase(ERK)andp38mitogen-activatedprotein(MAP)kinasearerequiredforhydrogenperoxide-mediatedphospholipaseDactivationinratpheochromocytomaPC12cells.Neuroreport12⑽:2271-2275,2001
⒕WangS,BannoY,NakashimaSandNozawaY.EnzymaticCharacterizationofPhospholipaseDofProtozoanTetrahymenacells.JournalofEukaryoticMicrobiology48⑵:194-201,2001
⒖WangS,NakashimaS,NumataO,FujiuKandNozawaY.Molecularcloningandcell-cycle-dependentexpressionoftheacetyl-CoAsynthetasegeneinTetrahymenacells.BiochemcalJournal343:479-485,1999
⒗WangS,NakashimaSandNozawaY.Stress-responsivechangesinthemRNAlevelsofMAPK-relatedproteinkinase(TpMAPK)andNIMA-relatedproteinkinase(TpNrk)inTetrahymenacells.EuropeanJournalofProtistology35:275-280,1999
⒘NakashimaS,WangS,HisamotoN,SakaiH,AndohMandNozawaY.Molecularcloningandexpressionofastress-responsivemitogen-activatedproteinkinase-relatedkinasefromTetrahymenacells.JournalofBiologicalChemistry274:9976-9983,1999
⒙WangS,NakashimaS,SakaiH,NumataO,FujiuKandNozawaY.Molecularcloningandcell-cycle-dependentexpressionofanovelNIMA(neverinmitosisinAspergillusnidulans)-relatedproteinkinaseinTetrahymenacells.BiochemicalJournal334:197-203,1998