爱华网国际权威杂志2011发表中国学者研究：首次报道了肠道菌群参与性早熟的发病过程。上海中医药专家提出预防早熟注意事项与中药治疗药方。欧盟认为含双酚A奶瓶会诱发性早熟，从2011年3月1日起，禁止生产含化学物质双酚A（BPA）的婴儿奶瓶。一些奶厂在盲目提高奶牛产奶量的情况下，会使用激素药品。显然，哪些类“食品”对自然状态肠道菌群造成潜在干扰危害，或可能含激素或类激素成分，为了孩子们的健康，无论家里还是在学校，必须远离这些类“食品”！2011年的报道：中国内地儿童早熟发病率，从十年前的0.5%到现今的5%，也呈现着快速增长趋势。2004年的研究：性早熟女童的骨骼发育加速、成熟提前,且病情越重,其加速、提前的程度越严重。中国足协2011年对3306名少年球员测骨龄：690名占大约20%球员骨龄超过实际年龄，最多超过实际年龄3.8岁。“最多超过实际年龄3.8岁”与早熟女童提前成熟程度类似，是否揭示男童中早熟的实际比例比目前单纯以其他方面性特征检测出的早熟男童比例更高？
A 2011 report: The incidence of earlypuberty in inland China, from ten years ago 0.5% has increased toat present 5%, appearing a rapid growth trend. 2004 study: In girls with precociouspuberty, bone development accelerated, matures in advance, andillness is more serious and accelerate with the more serious degreeof puberty advance. China Football Association in 2011 examinedbone age of 3306 youth players: Bone age of 690 players accountingabout 20% exceeded their actual age, maximum exceeding 3.8 years ofage. “Bone age with greatest difference toactual age was 3.8 years”, is similar to the age advancementof early puberty girls, does this reveal the actual prevalence ofearly mature boys is higher than determined only by judgment fromother aspects of sex characteristics? International authoritativejournal 2011 publish Chinese scholars study: For the first timereport gut flora participate the illnesscourse of precocious puberty. Shanghai Chinese traditional medicinespecialists early puberty prevention notes and Chinese traditionalmedicine prescription. EU considers that feeding-bottlescontaining bisphenol A (BPA) induceprecocious puberty, from March 1, 2011forbid production of feeding-bottles containing BPA.To blindly increase milk production,some farms will use hormones drugs to the cows.It is obvious, what kinds of “food”cause potential disruption harm to the natural conditionsof gut flora, or mightcontain estrogen or similar effect substance, for thehealth of children, at home as well as at school, should keep awayfrom such kinds of “food”!
中国为何女童性早熟急剧十年增加为十倍而且男女儿童骨骼提前成熟？
Why Does Precocious puberty Rapidly Increase in ChineseYoung Girls Ten Years Increase Ten Fold, And Bone Age of ChildrenExceed Their Actual Age?
-- 禁止抗草甘膦转基因作物原料进口、开发、种植、销售理由之220
编译者：陈一文（cheniwan@mx.cei.gov.cn）
Translated & Edited by ChenI-wan
《转基因技术与人类安全》研究专家、80年代前全国青联委员
“GMTechnology & Mankind Safety”researcher
《新浪网》“陈一文顾问博客”：http://blog.sina.com.cn/cheniwan
中国专家：女孩性早熟三大危害：[1]
Chinese Specialists: Three major harms of early puberty togirls: [1]
女孩性早熟危害一， Early puberty harm No.1, 卵巢发育有一定规律性，女性一生几个卵子是定的，生育能力只有三四十年，卵巢这么早就开始发育、排卵，以后卵巢会有早衰的问题。 Ovarian growth have certain regularity, the total number of ovumfor women over her life is definite, she also only has thirty tofourty years capable of fertility, if the ovarian develops andbegins ovulation so early, her ovarian will also prematureearlier. 女孩性早熟危害二， Early puberty harmNo.2, 性征提早出现的同时，往往伴随有骨骼生长的加速，暂时看起来比同年龄的儿童长得快、长得高，但由于其骨骺提前融合，所以最终身高往往比正常人矮小，这对孩子的正常发育并不利。 When sex characteristics appears early, it at the same time isoften associated with bone growth acceleration, such childrentemporarily looks better than those of the same age, grow fasterand taller during their childhood, but because ofearly fusion ofepiphysis, such children at older ages often are shorterthan normal, causing negative effects to normaldevelopment. 女孩性早熟危害三， Early puberty harmNo.3, 对孩子整个人生的成长道路都会产生非常大的影响。如会让孩子感到很自卑等。性早熟严重影响孩子的身心健康。由于其青春期提前，性征提早出现，在女孩往往还在上小学的年龄就出现乳房发育，甚至月经来潮，此时孩子的智力和性心理尚未成熟，生活上还不会完全自理，容易引发多种问题。而且性早熟的孩子，可能因自己在体型上与周围小伙伴不同，而产生恐惧和不安，影响其正常的生活与学习，因此也给家长造成精神上和照料上的负担。 Early puberty has great impact on the growth and life of suchchildren. Such as making them feel very inferiority, etc. Neotenyseriously influences the health of body and mind of such children.Because adolescence advance, sex characteristics, breastdevelopment, and even periods begin toappear with such girls at elementary school agewhen the child's intelligence and psychological are not mature andstill can not completely take care of themselves, can lead to avariety of problems. Precocious puberty children, because findingthemselves different to their friends around, in size and otheraspects, tends to produce fear and upset among them, which affectstheir normal life and study, and causes burden to their parentsmentally and additional care. |
The 4th risk of "Early puberty" forgirls: They have an increased risk of breast cancer and uterinecancer, … because these girls have more time to be exposed to theestrogen hormone. [2]
“青春期提前”对女孩子们第四项风险：成年后“她们患乳房癌与子宫癌的风险提高，…因为这些女孩子更长时间暴露于雌激素。”[2]
Pubertystarting earlier for many girls: study, 许多女孩子们青春期到来的较早：研究 Jennifer Ashton, CBS News, April 12,2011 詹妮弗·阿什顿，美国CBS新闻，2011-04-11 Girlsare reaching puberty in life earlier than ever, researchshows. 一项研究表明，女孩子们比过去早的多进入青春期。 About15 percent of American girls now begin puberty by age 7, accordingto a study of 1,239 girls published last year in the journalPediatrics. One in 10 white girls begin developing breasts by thatage - twice the rate seen in a 1997 study. Among black girls, 23percent hit puberty by age 7. 根据2010年《小儿科》杂志发表的对1,239位女孩子进行的一项研究，美国女孩子们大约15%于7岁开始进入青春期。白人女孩子每10位就有一位7岁开始乳房发育– 这是1997年进行的一项研究的两倍。在黑人女孩子中，23%在7岁开始进入青春期。 On "TheEarly Show" CBS News Medical Correspondent Dr. Jennifer Ashton, anOB-GYN who specializes in adolescent care, said "early puberty,"also known as "precocious puberty," has risks forgirls. CBS新闻医学记者、青春期专家詹妮弗·阿什顿说，“青春期提前”，也称之为“早熟青春期”，对女孩子们有风险。 "Youhave to remember, this is occurring at a time of childhooddevelopment where all girls and children want to do is fit in andlook like the person sitting next to them," Ashton said. "It cangenerate a lot of fear. It's not cute. Adults can look at it andsay, 'Oh, how cute.' It's really an adult body, a developing adultbody in a child's age.'" Ashtonsaid the effects on girls can be emotional as well asphysical. “你必须记得，这发生在童年发育期间，所有的女孩与孩子都想合群，长的像旁边的人一样”，阿什顿说。早熟“能够造成很多恐惧。不是乖巧的事。有的成年人见到后说，‘奥，真乖巧’。她真的有一个成年人的身体，在童年发育了成年人的身体’”。阿什顿说，早熟对女孩子们的影响既是情绪上的，也是身体上的。 "Weknow that girls of that age can suffer from low self-esteem," shesaid. "They can be subjected to more peer pressure, increased risksof eating disorder, even depression. They are known to participatein sexual activity in an earlier age because of this. Also, theycan be shorter because we know that estrogen is one of the keyhormones in puberty closes off the growth plates and girls will notbe as tall as if they went to puberty in a laterage." “我们知道这个年龄的女孩能够遭受低自尊的折磨”，她说。“她们受到被更多凝视的压力，饮食失调的风险更大，甚至因此感到沮丧。人们了解这样的女孩因此而更低年龄涉入性活动。而且，我们知道雌激素是青春期关闭生长面的关键激素之一，导致这些女孩成年后较矮，她们的身高不如迟些进入青春期那样高。” So whyis this happening? 为什么发生这样的情况？ It'snot clearly understood why this occurs, Ashton said, but some pointto the rise in obesity. 女孩子早熟为什么发生的原因不清楚，阿什顿说，但是有些人指向肥胖。 "Bodyfat generates the hormone estrogen, partially," Ashton said."Estrogen is part of the hormones that triggers puberty. A lot morechildren are overweight and obese. Environmental exposures, thingslike BPA (Bisphenol A) that are ubiquitous in our environment canhave hormone-like activity and research is ongoing as to whetherthat plays a role. And your family history - if your mother wentthrough early puberty, you have a greater chance of going throughearly puberty, as well." “体脂肪产生部分雌激素”，阿什顿说。“雌激素是触发青春期的激素。许多孩子过重与过度肥胖。环境暴露，例如BPA（双酚A）在我们的环境中无处不有，可以发挥激素样的获得，有关的研究正在了解它是否发挥这方面作用。还有你的家庭史– 例如你的母亲是否早熟，如果是的话，那么你早熟的机会也较大。” Early puberty could affect girls asthey get older, Ashton said. They have an increased risk ofbreast cancer and uterine cancer, she said, because these girlshave more time to be exposed to the estrogenhormone. 青春期提前可能在这些女孩年纪更大些时影响她们，阿什顿说。她们患乳房癌与子宫癌的风险提高，她说，因为这些女孩子更长世界暴露于雌激素。 "It'snot a trivial thing by any means," Ashton said. “无论从哪方面讲，这不是可以忽略的琐事”，阿什顿说。 Sherecommends talking to a pediatrician if parents notice signs ofpuberty at a young age. 如果父母注意到幼年进入青春期的迹象，她建议应当找小儿科医生咨询。 "Thiscould be a very frightening process for a child as well as aparent," Ashton said. “对于孩子以及父母来讲，这都可能是一个令人可怕的过程”，阿什顿说。 Ashton is the author of"The Body Scoop for Girls." 詹妮弗·阿什顿是《身体早熟的女孩子们》的作者。 |
中国情况：
China situation:
2004年的报告：中国儿童性早熟平均发病率是1%；广州儿童“性早熟”发病率已由10年前的0.5%上升至1.3%；广州孩子进入青春期的年龄由原来的平均13岁普遍提前到11岁；[6]
Areport in 2004: China early puberty average incidence was 1%;Guangzhou's children "precocious puberty" rates was 0.5% 10 yearsago which has now increased to 1.3%; Guangzhou children commonlyenter the age of adolescence when they reach 11 years old, comparedwith the original average 13 years; [6]
2004年的研究论文：“结论(1)性早熟女童的骨骼发育加速、成熟提前,且病情越重,其加速、提前的程度越严重。(2)中药具有明显减慢患儿骨骼发育,延缓骨骼成熟的作用。”[7]
Astudy published in 2004: “Conclusion: (1) Girls with precocious puberty, bonedevelopment accelerates, matures in advance, and illness is moreserious and accelerate with the more serious degree of pubertyadvance. (2) Traditional Chinese medicine has obvious slowingeffect on children skeleton growth, and delays bone maturedevelopment.” [7]
中国足协2011年对3306名少年球员测骨龄：690名占大约20%球员骨龄超过实际年龄，最多超过实际年龄3.8岁[8-9]
China Football Association in 2011 examined bone age of3306 youth players: Bone age of 690 players accounting about 20%exceeded their actual age, maximum exceeding 3.8 years ofage [8-9]
足协召开了全国青少年联赛赛区申办工作及骨龄测试会议，根据最新数据，目前接受骨测的3306名球员中，骨龄超标球员有690人。足协竞赛部副部长唐峰昨天表示，这690名球员中多数是身体发育较早，年龄作假的情况只是少数。依据北京体育大学公布的骨测数据，骨龄比实际年龄相差最大为3.8岁。
The football association has held a national youth league bid andbone age testing conferences, according to the latest data, amongthe 3306 players accepting the bone age test, those of which boneage exceeds actual age players accounted to 690 people. Tang Feng,vice minister of competition of the football association, saidyesterday, most of the 690 players experiences earlier bodydevelopment, with only a few false age cases. According to the boneage examination data, the bone age with greatest difference toactual age was 3.8 years.
【陈一文顾问评论：“最多超过实际年龄3.8岁”与早熟女童提前成熟程度类似，是否揭示男童中早熟的实际比例比目前单纯以其他方面性特征检测出的早熟男童比例更高？是否揭示应当将骨龄提前成熟程度作为男童是否早熟重要判据之一？男童骨龄提前的机制与原因与女童早熟的机制与原因是否有差异？】
【Advisor Chencomments: “Bone age with greatest difference toactual age was 3.8 years”, is similar to the age advancementof early puberty girls, does this reveal the actual prevalence ofearly mature boys is higher than determined only by judgment fromother aspects of sex characteristics? Does this reveal that shouldalso consider advance extent of bone age as one of the importantcriterions for determining early mature boys? Is the mechanism andcourse of advance bone age for early mature boys the same as themechanism and course of advance puberty ofgirls?】
2001-2005浙江沿海地区调查结果：[10]
Result of 2001 – 2005 survey alongcoastal area of Zhejiang province: [10]
在通过对2.3万名儿童(幼儿园大班至小学三年级)的调查研究,课题组发现:2.3万人中查出性早熟84例，其中男9例，女75例。结果：浙江沿海地区小儿性早熟发病率达到了0.38%。
In survey of 23,000 children (kindergarten to the primary schoolgrade three), task group found 84 cases of precocious puberty, themale 9 cases, female 75 cases. Result: Zhejiang coastal areachildren precocious puberty incidence to 0.38%.
调查显示，城镇儿童性早熟发病率为0.45%，高于农村的0.32%。经济发达地区的发病率0.50%，高于欠发达地区的0.32%，而公路旁及工厂污染严重区域，比相对少污染区域发病率显著增高，分别为0.52%和0.28%。这说明，性早熟受环境因素影响，而且性早熟的发病与母亲初潮早，服用滋补药和饮食习惯等有关。
Investigation shows, town early puberty rate was 0.45%, higher thanthe 0.32% of the rural areas. The economic developed area incidence0.50%, higher than 0.32% of the less developed regions; areas alonghighways and factory pollution area incidence 0.52% compared withless pollution areas 0.28%, respectively.This shows that precocious puberty is influenced by environmentalfactors, and influenced by mother early menarche, take nourishingmedicine and diet and so on.
上海2005年公布的报告：[11]
Shanghai 2005 report:[11]
2005年复旦大学公共卫生学院儿童少年卫生学教研室与复旦大学儿科医院联合进行的临床流行病学调查显示，目前上海地区儿童性早熟的患病率为 1%左右，仅次于肥胖症 ，占小儿内分泌疾病的第二位。此次调查是我国第一个最大宗性早熟的发病统计：3万余名被调查者，1%的发病率，与国外报告的性早熟平均发病率0.7%-1.5%比较接近。
A epidemiology investigation jointly carried out by the Children& Youth Health Staff Room, Public Health College ofShanghai Fudan University, and Pediatric Hospital of FudanUniversity shows, the prevalence of early puberty in Shanghai isaround 1%,ranking the second illness only to obesity, accounting for thesecond pediatric endocrine diseases. The investigation is China'sfirst precocious puberty survey statistics: from over 30,000respondents, incidence is 1%, which is rather close to overseasreported precocious puberty average rates 0.7% -1.5%.
2009年的调查：我国女孩青春期发育年龄平均为9.2岁，比30年前的12.5岁提前3.3岁[12]
A 2009 Survey: Chinese girl’s mean puberty age on average is 9.2 years,3.3 years earlier than 12.5 years 30 years ago[12]
2009年，中华医学会儿科学分会内分泌及遗传代谢病学组公布的调查显示，我国女孩青春期发育年龄平均为9.2岁，比30年前的12.5岁提前3.3岁。
In 2009, the Pediatrics Endocrinology & GeneticMetabolism Branch of Chinese Medical Society published a surveyshowed that Chinese girl’s mean puberty age on average is 9.2years, 3.3 years earlier than 12.5 years 30 yearsago.
环境中类激素污染物的影响和摄入含有性激素的食物或药物等是助推青春期提前的主因。
Theeffect of hormone-like contaminants in the environment, intake offood or medicine containing sex hormones, are the main reasonspromoting early adolescence.
重庆儿童医院2010年的报告[13]
2010 Chongqing Pediatric Hospital Report [13]
长期致力于儿童性早熟研究治疗的重庆儿童医院雷培芸教授确认，该院1990年内分泌科性早熟门诊成立之初，每年收治性早熟患儿不过30例，到1998年时达到300例。2004年时，达到1000多例。最近几年，患儿每年约2000例。根据这种速度计算，性早熟患儿每年以超过20%的速度递增。
Prof. Lei Pei-yunstudied children early puberty and treatment for a long time at theChongqing Pediatric Hospital. Prof. Lei confirmed, when theEndocrinology Dept. Early Puberty Clinic was established in 1990,every year it only received around 30 patients with early puberty,but received 300 such patients by 1998. By 2004, this increased toover 1000 patients. During recent years, they received about 2000patients each year. Calculation accordingly, the incidence of earlypuberty increases at a rate over 20% each year.
国际权威杂志2011发表中国学者研究：首次报道了肠道菌群参与性早熟的发病过程[14]
International authoritative journal2011 publish Chinese scholars study: For the first timereport gut flora participate the illnesscourse of precocious puberty [14]
上海中医药大学中医方证与系统生物学研究中心张永煜教授、贾伟教授，上海交通大学附属儿童医院的科研人员合作研究，发现性早熟女童的代谢模式与正常女童存在明显差异，且体重偏重，进一步研究发现女童性早熟发病过程与色氨酸、酪氨酸、三羧酸循环等多条代谢通路发生改变直接相关。
Prof. Zhang Yongyu, Jia Wei, Chinese Traditional MedicinePrescription Examination & Systems Biology ResearchCenter of Shanghai University of Traditional Chinese Medicine,jointly with science research members of the Children’sHospital affiliated to Shanghai JiaotongUniversity, found obvious difference metabolic patterns betweenprecocious puberty girls to normal girls, the former tend to haveheavier bodies, and through further study found that the course ofprecocious puberty disease is directly related to alterationof three major perturbed metabolic pathways,catecholamine, serotonin metabolism and tricarboxylic acidcycle.
实验中还检测到6种与性早熟发病相关的激素，尤其是催乳素（prolactin）、促黄体生成素（luteotropic hormone,LH）、卵泡刺激素（follicle-stimulating hormone,FSH）、雌二醇（Estradiol, E2）与健康女童相比分别增高了0.7、1.5、1.6和11.5倍。并首次报道了肠道菌群参与性早熟的发病过程，以及代谢组学方法在疾病诊断方面的应用前景。这些研究结果还为剖析中医药治疗性早熟提供了潜靶点。
The study identified 6 kinds of hormones related to development ofprecocious puberty disease, especially prolactin, luteotropichormone (LH), follicle-stimulating hormone (FSH) and estradiol(E2）increases 0.7, 1.5, 1.6 and 11.5respectively compared tohealthy control groups. Thestudy was also the first to report that an alteration in symbioticgut microbial (gut flora)composition is involved in the development of CPP(Central Precocious Puberty)condition, and the application prospect ofmetabonomics in disease diagnosis method, these results of theresearch analyzed potential targets for precocious pubertytreatment by traditional Chinese medicine.
该研究得到国家自然科学基金和上海市教委“085”学科内涵建设经费资助，研究成果于2011年10月25日在国际权威期刊《Molecular and CellularProteomics》杂志上在线刊出，受到业内高度关注和评价。[15]
This study was supported by the National Nature Science Foundationand the Shanghai Education Committee “085” subject connotationconstruction supporting fund. The study was published on Oct. 25,2011 by the international authoritative journal “Molecular andCellular Proteomics”, and received strong attention and appraisewithin the concerned academic field. [15]
上海中医药专家提出预防早熟注意事项与中药治疗药方 [16]
Shanghai Chinese traditional medicinespecialists early puberty prevention notes and Chinese traditionalmedicine prescription [16]
在中医药治疗方面，专家认为儿童性早熟的临床征候为“肾阴虚，相火旺”，提出滋肾阴、泻相火的治疗原则，用生地、知母、黄柏等十几味中药制成方剂，疗效比较理想。
Regarding treatment of precocious puberty with Chinese traditionalmedicine, specialists consider the clinicalsymptom of precocious puberty is “syndrome of hyperactivity of fire due todeficiency of kidney Yin”, propose treatment principle of “Moistkidney Yin, effuse hyperactivity of fire”, propose a prescriptionbased on Shengdi, Zhimu, Huangbo etc. have rather idealeffects.
日常饮食方面，上海中医药大学张永煜教授等建议，少食禽颈、蚕蛹、鸡胚等；少食反季节蔬果、洋快餐、油炸类食品；少食保健品，如动物初乳、蜂王浆、蛋白粉、各种“长高长壮”口服液，以及具有补益作用的中药，如冬虫夏草、人参、桂圆、花粉、哈士蟆油等。
Regarding daily diets, Prof. Zhang Yong-yu,Shanghai University of TraditionalChinese Medicine, and others suggest, should eat less necks ofpoultry, silkworm pupae, chicken embryo etc., eat less againstseason vegetables, Western fast-food, oil fried food; eat lessHealthcare products, like animal foremilk, royal jelly, proteinpowder, all kinds of “grow high, grow strong” oral administrationliquids, and avoid healthcare supplementary Chinese medicine,like Chinese caterpillar fungus, Ginseng,Longan, Flower powder, Toad oil etc.
此外，还需特别注意环境污染，如洗涤剂、农药、塑料制品及过度光照等刺激。
Should also pay special attention to environment pollution,like detergent agents, pesticides, plasticproducts and excessive sunshine etc.
郑州儿科专家：避免不当食物导致性早熟 [17]
Zhengzhou pediatrics specialist: Avoid notappropriate food causing precocious puberty[17]
Is precocious puberty generated byfood?
但性早熟很多是“吃”出来。据郑州市儿童医院儿童保健中心主任刘金权介绍，现在许多食品添加激素，尤其是油炸食品如炸鸡翅、炸薯片及市面上流行的洋快餐等，都可能导致孩子脂肪堆积，发育过早。刘金权认为一些进口水果、催熟水果也含大量激素，容易导致孩子发育异常。
But much precocious puberty are generated by "eating". According toLiu Jin-quan, Director, Children Healthcare Center ofZhengzhou Pediatric Hospital,many food contain hormones,especially fried foods such as fried chicken wings, fried potatochips and other Western fast food favored in the market, are likelyto cause the child adipose accumulation and abnormal earlydevelopment.
浙江儿科专家：孩子发育前不要长期大量吃豆制品[18]
Zhejiang pediatrics specialist: Before childdevelopment is completed, children should not eat large amounts ofsoybean processed products [18]
浙江省人民医院儿科副主任医师吴美珍解释说，大量食用豆制品会引起孩子性早熟，主要是大豆及制品内含有大豆异黄酮，是一种植物雌激素。它的化学结构雌激素十分相似，可以作为雌激素替代物促进成骨细胞生长。
WuMei-zhen, vice director, pediatrics dept. of Zhejiang People'shospital, explained, eating large amounts of soy products causeschild precocious puberty, mainly is because soybean and itsproducts contains soybean isoflavone, a kind of plant estrogen. Thechemical composition of isoflavone is very similar to estrogen,which can act as a estrogen substitute to promote bone cellgrowth.
根据大豆制品的特殊作用，医生起初将其用于更年期妇女骨质疏松的治疗。更年期妇女由于卵巢功能减退，体内雌激素水平急剧下降，对成骨细胞的刺激减弱，容易造成骨质疏松。研究发现，给更年期未绝经妇女服用大豆异黄酮后，大豆异黄酮可以作为雌激素替代物发挥作用，从而达到防治更年期未绝经期妇女骨质疏松。因此，医生会鼓励处于更年期的妇女可以多吃些豆制品。
According to the special function of the soybean products, doctorsat first applied it in the treatment of osteoporosis of menopausalwomen. Due to ovarian function decline of menopausal women, bodyestrogen level falls sharply; stimulation to osteoblast issignificantly reduced, easy to cause osteoporosis. Research foundthat soybean isoflavone can be used by post-menopausal women as anestrogen substitute to prevent osteoporosis. Therefore, doctorswill encourage in menopausal women eat more soybeanproducts.
然而豆制品内的植物雌激素如同一柄双刃剑，对成年人有一定好处但对于孩子却是一剂“催化剂”，大量服用豆制品，植物雌激素会扰乱孩子正常的生长发育，最直接的后果是性早熟，而早熟如未及时发现，及时干预，会使孩子骨龄提前，骨龄提早愈合则是导致青少年身材矮小的主要原因之一。因此专家提醒，发育前的儿童最好不要长期大量吃豆制品，具体吃多少，医生会根据孩子的实际情况提出建议。
However, the plant estrogen of soybean products acts like a doubleedged sword, has certain benefits to adults, but for children islike a dose of the "catalyst": if children eat a lot of soybeanproducts, the plant estrogen would disrupt the normal growth anddevelopment of the child, with the most direct consequences beingprecocious puberty, which if not found in time, and if timelyintervention is not adopted, could advance the child’s bone age,cause early healing of bone agewhich is one of the main reasons for shortstature. Therefore experts remind, it is necessary not tocontinuously eat a lot of soybean products for a long period oftime before full development of children, according to the child'sactual situation doctors will propose specific how much soybeanproducts are appropriate.
欧盟认为含双酚A奶瓶会诱发性早熟，从2011年3月1日起，禁止生产含化学物质双酚A（BPA）的婴儿奶瓶。[19]
EU considers that feeding-bottlescontaining bisphenol A (or BPA for short) induce precocious puberty, from March 1, 2011forbid production of feeding-bottles containing BPA.[19]
前段时间，欧盟认为双酚A在加热时能析出到食物和饮料当中，它可能扰乱人体代谢过程，对婴儿发育、免疫力有影响，甚至致癌。欧盟从今年3月1日禁止生产含双酚A的塑料奶瓶，6月起禁止任何双酚A塑料奶瓶进口到成员国。
Some time ago, EU considers that when heated BPA could separate outinto food and drinks, might disrupt metabolic process of humans, have negativeeffect on infant development and immunity, and even cause cancer.EU has from March 1 forbid production of feeding bottles containingBPA, and from June forbid import of any feeding bottles containingBPA into members of EU.
专家称奶源有含雌激素可能 [20]
Specialists says there is possibilityof source of milk containing estrogens [20]
三聚氰胺的阴影尚未散去，又有媒体爆出某种奶粉疑致婴儿性早熟，乳房开始发育，卫生部2010年8月10日回应称还不能断定早熟婴儿与特定的食物或者环境之间有联系。记者采访了有关专家对相关问题谈了自己的看法。
The shadow of Melamine has not been completely cleared, mediastarts reporting about suspects that a brand of baby milk powdermight cause precocious puberty and breast development of infants.The Ministry of Health on August 10, 2010 responded that they cannot conclude connection between the precocious baby and particularfood or the environment. The reporter interviewed concerned expertwho expressed their opinions to concerned issues.
中国兽医药品监察所王树槐研究员
Wang Shuhuai, Researchers, China Veterinary Drug MonitoringStation
京华时报：卫生部发言人称奶粉里不允许检出雌激素，但您在发布会上称“规定了不得检出的限量标准”，请问到底允不允许奶粉中含有雌激素？
Jinghua Times: TheMinistry of Health spokesman said powdered milk does not allowdetection of estrogen, but you in the conference stated that "therules set the standard limit of detection", excuse me, is milkpowder allowed or not allowed to containestrogen?
王树槐：发言人所称的奶粉中不允许检出雌激素是指不能检出人为添加的合成雌激素物质。我所说的雌激素是指奶牛体内天然产生的激素，这些激素人体内也含有。包括两类激素，一个是促卵泡激素和促黄体激素。奶粉中如果有这两类激素，并且含量符合国际组织的标准，这是农业部允许的，是正常现象。
Wang Shuhuai: Thespokesman said milk powder is not permitted detect syntheticestrogen material add to the product. The estrogen I mentionedrefers to natural estrogen hormones existing within the cow’s body,these hormones also exist within human body. This includes twotypes of hormone, the follicle-stimulating hormone and promoteprogestin. If milk powder contains these two types of hormones, andtheir content level conforms to international organizationstandards, this is allowed by the Ministry of Agriculture, is anormal phenomenon.
中国医师协会儿童健康专业委员会委员丁宗一
DingZongyi, Committee member, Children Health Special Committee toChina Medical Doctor Association
京华时报：奶粉制造的哪个环节容易出现添加激素或激素残留的问题？
Jinghua Times: In whichlink of milk powder manufacturing is more likely occur the problemof adding hormone or hormone residues?
丁宗一：在奶粉加工环节是没有必要添加激素的，因为它不会增加口感，不会提高产量，不会降低成本，反而会大大拉高生产成本。从无利益、无动机的角度而言，这个环节不可能。但是在原料奶环节是有可能的。一些奶厂在奶牛生病的情况下，在盲目提高奶牛产奶量的情况下，会使用抗生素和激素药品。因此，不排除这个阶段出现问题。
Ding Zongyi: It is not necessary to add hormones during the milkpowder process, because it won't improve the taste, will notincrease the production, will not reduce cost, and insteadsignificantly increase cost of production. From the perspective ofno benefit, no motivation, it is not possible. But, in cases of sick cows, and toblindly increase milk production, some farms will use antibioticsand hormones drugs. Therefore, can not eliminate such problemsexist at milk cow farms.
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BPA plastic feeding-bottles induce precocious puberty，EU from today forbids, supermarket inChina are still selling, Xinjingbao Daily, 2011-03-01
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Jinghua Times, Experts consultation on causes of baby girlsprecocious puberty, at present can't judge if related or not withthe milk powder, 2010-08-11
http://news.cntv.cn/society/20100811/100279.shtml
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陈一文：中国真正共产党人三代真诚的朋友
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1988-2004美国肝癌倍增中国肝癌人数超世界肝癌人数一半
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